STUDY THE EFFECTS OF DRENCHING OF ETHANOLIC EXTRACT OF TARAXAC UM OFFICINALE LEAVES AND ATROVASTATIN ON SERUM ENZYMATIC ACTIVITY CHOLESTEROL LEVEL; REPRODUCTIVE EFFICIENCY AND ON THE STRUCTURAL CHARACTERISTICS OF PITUITARY-THYROID-OVARIAN-UTERINE AXIS OF LOCAL ADULT CHOLECYSTOCTOMISED FEMALE RABBITS

Abstract

This study had been done on twenty four healthy adult local female rabbits of_ mean body weight of 2 kgm and mean age of 5 months were randomly allocated into fourgroups of six ainmals eash; all groups were fed during the period of experiment on a dietcontained 0.5 % cholesterol and 14% coconut oil. The first group was regarded as controland received 3ml of physiological saline orally‘ for a month. The second group wasdrenched ethanolic extract of Taraxacum ojficirzale (500 mg/kg/day) for one month; thethird group first subjected to cholecystoctomy (removal of gall bladder) then drenched 500mg/kg/day ethanolic extract of T. oflicinale for month also. The fourth group was treatedwith atrovastatin (0.4 mg/kg/day) for one month also. Those females were joined withmales after treatment for a week to study the effect on fertility and reproductive capacityand on fetal growth. Blood samples were taken from all groups at the end of the treatmentto know the effect on serum cholesterol and on enzymatic activity then after killing theanimals the following organs were taken for histological study.They are pituitary and thyroid glands; ovaries and uterin from each animal of each. group. The following results were obtained:-1. The ethanolic extract of Taraxacum ofiicinale caused highly significant increase(p<0.01) in SGOT.2. Atrovastatin caused significant increase i(p<0.05) in SGOT.3. Drenching Tofiicinale extract didnot cause any significant change in SGOT ofcholecystoctomised female rabbits. ’4. The ethanolic extract of Tofficinale and atorvastatin had caused significant decrease(p<0.05) of SGPT in intact female rabbits but caused highly significant decrease

Keywords

Uterine, Enzymes, extract