A study of the Cisplatin effect on testis of Infected mice with Echinococcus granulosus


Abstract:In the present work, 25 male Balb/c mice have been used ( 5 mice are not infected with Echinococcusgranulosus and untreated with cisplatin used as a control group),(10 infected with Echinococcus granulosusuntreated mice) and (10 infected with Echinococcus granulosus treated with Cisplatin 100 mg/m2 weekly forthree weeks),these 20 mice considered as test group. the histopathological study of testis specimen show thatthe infected untreated groups have no histopathological changes in comparism to the control group, while theinfected and treated group shows significant histopathological changes such as that the seminiferrous tubulesdestroyed completely, there is loss of many seminiferrous tubules, extensive necrosis in rete testis and thecells of the efferent duct are flat and attenuated arrangement singly or in clusters with round nuclei.