Treatment of Scabies by Sulphur Ointment Mixed with Clobetasol Dipropionate Ointment

Abstract

Back ground: Scabies is one of the common skin diseases all over the world including Iraq, which is caused by the mite Sarcoptes scabiei, many remedies have been used for the treatment e.g. sulphur.Objectives: The aim of the study is to compare the effectiveness and the adverse effects of topical sulphur ointment (5, 7.5 and 10%), mixed with clobetasol dipropionate ointment (0.05%) and sulphur ointment alone, in patients with human scabies.Patients & Methods: Five hundred patients were involved in this study, which was done in a private clinic in Baquba City, Diyala governorate, Iraq, during the period Jan. 2004 to May 2008. They were 350 males and 150 females, their ages ranged from 2 months to 80 years, with a mean age of 30 years. They were fully interrogated and examined regarding their complain and diagnosed clinically as scabitic patients. The patients were divided randomly into 2 groups: group one consisted of 300 patients, was treated by topical sulphur ointment, mixed with clobetasol dipropionate ointment and the second group consisted of 200 patients, was treated by topical sulphur ointment alone. Both groups were followed up for 3 weeks.Results: The study showed that the cure rate of both types of treatment was nearly similar (group one 95% and group two 96%). None of the patients in group one developed irritant contact dermatitis as a result of treatment, but 2% developed steroid acne, and 10% of the patients in group two developed irritant contact dermatitis. The relapsing rate was 10% in the group one and 7% in the group two.Conclusion: In conclusion the topical sulphur ointment when mixed with clobetasol diproboinate ointment gave good therapeutic results in the treatment of human scabies, without adverse effect of contact dermatitis.Key words: Scabies, Sarcoptes, Sulphur, Clobetasol dipropionate, Malathion.