Dermatofibrosarcoma Protuberans: "Epidemiological and Clinical Study"

Abstract

Background: Dermatofibrosarcoma protuberans is a locally aggressive invasive dermal and subcutaneous mesenchymal neoplasm. Males are affected more often than females. It typically occurs during the third and fourth decades of life.Objective: To determine the clinical, histopathogical and epidemiological aspects of dermatofibrosarcoma protuberans in Iraqi patients.Patients &Methods: This case series study was carried out in the Department of Dermatology & Venereology-Baghdad Teaching Hospital during the period from June 2000 to December 2006.Twenty patients with dermatofibrosarcoma protuberans were included in this work. Socio-demographic information, full clinical, dermatological examination and biopsy were done for each patient. Results: Twenty patients were involved in the present work, all showed typical clinical features of the disease. Their ages ranged from 7-75 (mean ± SD) (38.55 ± 21.33) years, while the duration of the disease ranged from 3-24 (mean ± SD) (23.28 ±10.53) months. There were 14(70%) males and 6(30%) females with a male to female ratio 2.3:1. The geographical distributions of these cases were: 9(45%) cases from South of Iraq, 11(55%) patients from Baghdad.The main sites involved were the extremities 10(50%) and 5(25%) for each one of the trunk and head. The clinical features of the diseases were not much different from what have been published in medical literatures .Histopathological study of lesions revealed the typical histological features of dermatofibrosarcoma protuberans in all cases. Conclusion: The present study confirmed that dermatofibrosarcoma protuberans is disease of male and it is the first report from Iraq recording cases from Middle and South regions only. Keywords: dermatofibrosarcoma protuberans, malignancy, clinical, epidemiological.