Lichen Planus and Hepatitis in Iraqi Patients

Abstract

Background: With time, it is becoming that idiopathic lichen planus (L.P) is being observed more and more in conjunction with diseases of altered or disturbed immunity. Such autoimmune diseases include ulcerative colitis, alopecia areata, vitiligo, dermatomyositis, morphoea and lichen sclerosus.Objective: The aim of the study is to clarify the possible association between L.P and active chronic hepatitis especially hepatitis B virus (HBV) infection.Patients & Methods: Fifty patients with lichen planus attending Department of Dermatology at Tikrit Teaching Hospital were enrolled in this study in the period December 2006 through to December 2006; their mean age (42.72), with standards deviation (±12.72). A full history and clinical assessment for each patient with lichen planus and conforming diagnostic were performed. All patients were screened for hepatitis B surface antigen (HBs Ag), antibody to hepatitis B core antigen (anti-HBc), aspartate transaminase (AST), and alanine aminotransferase (ALT).Results: were that lichen planus most common between 21 and 60 years were 60% males and 40% females. The percentage of new cases were 2%, the nonfamilial cases were 90% and familial cases 10%, most lesions on the cutaneous and mucosal (oral and genitalia) involvement (66%) and cutaneous only (34%). The dysfunction of liver test were positive in 16% and only (6%) from them have had HBsAg and anti-HBc positive.Conclusions: It can be concluded that HBV infection is lower among lichen planus patients, only (6%) have had HBsAg and anti-HBc positive. Therefore, it seems prudent to screen all patients with lichen planus by liver function test. Liver disease may consider a risk factor for lichen planus although not a specific marker for it and should be receptive to signs or symptoms of liver disease when evaluating patients with lichen planus. The link between lichen planus and chronic active hepatitis infection continues to be investigated and debated.Key Words: Lichen planus, Hepatitis.