Transition of Type 2 Diabetes Patients From Oral Hypoglycemic Agents to Insulin Therapy

Abstract

Background: The treatment options for type 2 diabetes have expanded rapidly in recent years with the development of new oral therapies, the abilities of these agents to lower blood glucose to reach and sustain glycemic targets in some patients is limited. Insulin has been wrongly viewed traditionally as a last resort to be used only when all other treatment options have been exhausted; however significant improvements in insulin therapy are beginning to remove the barriers to initiation of insulin replacement in type 2 diabetes. Objectives: To screen the criteria of type 2 diabetes patients who were treated with insulin in this sample study, and the effect of transition to insulin on glycemic parameters, in comparison to their follow patients who are still on oral hypoglycemic drugs Patients and Methods: Across-sectional design and a convenient sampling procedure were adopted to enroll 200 patients who met the inclusion criteria and were attending the National Diabetes Center for Treatment and Research in Al-Mustansiriya University during the period from 1st of February 2009 to the end of March 2009, each patient included in study sample were interviewed directly by similar questionnaire, same measurement and investigation were applied to all patients. Results: The means of age of onset and duration of diabetes mellitus for patients on insulin and patients on oral hypoglycemic agents therapy were (44.56±9.03)(48.91±9.45)(12.64±7.2)(6.91±6.38) years respectively, there was a statistically significant difference among means of the two groups, while there was no significant difference between means of all other criteria and glycemic indicator of both group.Conclusion: Apart from the means of age of onset and the duration of diabetes which shows significant difference between the two groups of patient in this study (those on Insulin therapy versus those on oral hypoglycemic agents and oral diet therapy), all other means of variable used in this study show no significant difference between the two groups of patients.Key words: Insulin – Type 2 diabetes mellitus.