Maternal and Cord Blood Nucleated Red Blood Cells Count in Women with Preeclampsia

Abstract

Background: Preeclampsia is a pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation which is typically characterized by hypertension, proteinuria, edema and fetal compromise.Patient and methods: A case -control study. Study design concluded at Al-Kadymia Teaching Hospital for the period from June 2007 to June 2008. The study population included hundred pregnant women delivered in the hospital. These women were divided into two groups; group A included fifty pregnant women who had preeclampsia and group B included fifty healthy pregnant women. A sample of umbilical cord blood and maternal venous blood were simultaneously taken within one hour of delivery, blood smears were prepared using Lieshman΄s stain and the number of nucleated red blood cell per hundred white blood cells in maternal and cord blood was determined and compared between the two groups. Any correlation of nucleated red blood cell counts in maternal and cord blood was also evaluated.Results: The nucleated red blood cell in cord blood of newborns in preeclampsia group was significantly higher than in the control group. A significant correlation was found between the maternal and cord blood nucleated red blood cell counts in preeclampsia group.Conclusion: Infants of preeclamptic women have higher nucleated red blood cell count at birth than control which means that preeclampsia may produce an erythropoietic response in the fetus. The positive correlation between maternal and cord nucleated red blood cell counts in preeclamptic patients indicates that may be the hypoperfused placenta plays a role in this correlation.Keywords: Maternal & cord blood, Nucleated RBC, Preeclampsia