The effect of atropine on heart rate with rapid sequence induction in neonates

Abstract

Background: neonates experience physiological responses toendotracheal intubation, including bradycardia and oxygen desaturation.The bradycardia may be associated with severe hemodynamicdisturbances like significant hypotension which may threaten patient'ssafety.Aims: To determine the effectiveness of single dose IV atropine, 5minutes before induction of anesthesia on reflex bradycardia tolaryngoscopy in sick neonate baby.Patients and Methods: In a randomized double blinded, placebocontrolled clinical trial, thirty neonates aged 1-10 days, term, 2.5-3.5kgand from both sexes, were enrolled to receive 0.02mg/kg IV atropine(n=15), as study group and placebo group had received equivalentvolume of normal saline five minutes before induction of anaesthesia(n=15), as control group. The induction technique was the same in allpatients. The incidence of bradycardia just after intubation wasrecorded.Results: data analyses showed that the overall incidence of bradycardiajust after intubation in the study group was significantly lower than thecontrol group.Conclusions: A single dose IV atropine five minutes before induction ofanaesthesia in neonate baby significantly decreases the incidence ofbradycardia after intubation.