Evaluation of lipid peroxidation, lipid profile and antioxidant status in patients with non-insulin dependent diabetes mellitus in Najaf / Iraq.

Abstract

Background:Diabetes mellitus arises when insufficient insulin is produced, or when the availableinsulin does not function correctly. Without insulin, the amount of glucose in the blood stream isabnormally high, causing unquenchable thirst and frequent urination. The body’s inability to store oruse glucose causes hunger and weight loss (1) . Type 2 diabetes – occurs when there is a severe lack ofinsulin due to the destruction of most or all of the beta (ß – cells) in the islets of Langerhans. Diabetesmellitus is considered to be one of a rank of free radical diseases which propagates complications withincreased free radical formation. Oxidative stress is increased in diabetes mellitus owing to the increasein the production of oxygen free radicals and a deficiency in antioxidant defense mechanisms. Lipidperoxidation of cellular structures, a consequence of increased oxygen free radicals, is thought to playan important role in atherosclerosis and microvascular complications of diabetes mellitus.Hyperlipidaemia has also been reported as one of the causative factors for increased lipid peroxidationin diabetes mellitus. The study was designed to find out the relationship between lipid peroxidation,and complication of diabetes mellitus and to estimate the mutual relationship between serumlipoproteins levels and diabetes severity (2).