Levels of Some Pro-inflammatory Cytokines in Pregnant Women with Polycystic Ovary Syndrome

Abstract

Abstract:The objective of this study is to determine levels of some pro-inflammatorycytokines (IL-12 and SIL-2R) in pregnant women with polycystic ovarysyndrome (PCOS) and also to determine incidence of spontaneous abortionduring first trimester in pregnant women with PCOS compared with non-PCOSpregnant women. This Study was performed on (93) women, consisted of:1- (63) pregnant women during the first trimester, which included:A-(33)PCOS pregnant women and subdivided into the following groups: (20)successful pregnant PCOS, (7) blighted Ovum PCOS and (6) missedabortion PCOS. B- (30) non-PCOS pregnant women, which included: (27)successful pregnant control and (3) non-PCOS pregnant women werewithdrawn from this study because of their abortion in first trimester.2- (30) non-pregnant subjects, which subdivided into the following groups:(18) non-pregnant PCOS and (12) non-pregnant control.Serum luteinizing hormone (LH), testosterone hormone levels and serumpro-inflammatory cytokines [IL-12 and sIL-2R] levels were measured in allsubjects. It is found that the incidence of spontaneous abortion {missed(18.2%)and blighted ovum(21.2%)} in first trimester of pregnancy for 33 women whichwas (39.4%) and it is 3.9 fold higher than incidence of spontaneous abortion{missed(3.3%) and blighted ovum (6.7%)} for 30 non-PCOS pregnant womenwhich was (10%). The LH levels were increasing significantly (P<0.05) in