Comparison between the Effect of Melatonin and Zinc sulfate in Prevention of cisplatin induced Nephrotoxicity in Rats


AbstractCisplatin is an inorganic complex; the therapeutic effects of it aresignificantly improved by dose escalation. However high-dose therapy withcisplatin is limited by its cumulative nephrotoxicity and neurotoxicity.The aim of study was to compare between the effect of melatonin and zincsulfate in prevention of cisplatin induced-nephrotoxicity in rats.Forty male albino rats weighing (200-250gm) were equally divided into fourgroups: normal group (0.2 ml isotonic saline group), control group "cisplatingroup" (12 mg/kg cisplatin, single dose I.P.), melatonin group (15 mg/kg I.P.)prophylactically one day prior to cisplatin administration and continued for further3 days, and zinc sulfate group (50 mg/ kg I.P.) prophylactically one day prior tocisplatin administration and continued for further 3 days.There was significant difference (p<0.05) between zinc sulfate and melatoninin reducing serum creatinine and BUN (melatonin more effective in reducing theseparameters), and there was no significant difference (p>0.05) between them inreducing serum malondialdhyde (MDA) and increasing serum glutathione (GSH).As a conclusion, melatonin (15 mg/ kg I.P.) and zinc sulfate (50 mg/ kg I.P.)had protective effects against cisplatin- induced nephrotoxicity in rats. Melatoninwas found to be more effective than zinc sulfate in its ability to reverse theabnormal renal function and preventing histopathological changes.Key words: cisplatin, melatonin, zinc sulfate, nephrotoxicity