Relationship of Thyroid Stimulating Hormone with Coronary Artery Disease in Patients Undergoing Diagnostic Coronary Angiography


In this cross-sectional study, a sample of 150 patients (88 men and 62 women) of age 53.28 9.6 years who underwent diagnostic coronary angiography. Blood was used for the measurement of serum thyroid stimulating hormone (TSH), free thyroxine (FT4) concentration and serum lipid profile total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein- cholesterol (HDL-C). Mean serum concentration of lipid profile across different groups of TSH level, (<0.38, 0.38- 4.31 and > 4.31 mIU/L) was calculated in order to study the association of TSH with prevalence of coronary artery disease CAD. The severity of CAD was scored as score (0) for those with smooth normal coronary artery while score 1, 2 and 3 for those with single, double and triple-coronary artery of ≥50% stenosis, respectively. Score 4 indicated left main coronary artery with 50% stenosis. The mean serum TSH was significantly higher in women than men (p=0.005). There was no significant difference between mean serum TSH level across different score groups (p=0.7). High level of TSH was observed in the multi-vessel disease, (score 2, 3 and 4 p=0.03). It was found that serum TC, LDL-C and TG increased while HDL-C decreased with increased TSH level. This study suggested that the high level of TSH is associated with multi-vessel disease and slight elevation of TSH also leads to changes in lipid profile that raise the risks of cardiovascular disorders.