Urinary tract infection among patients with bladder cancer : Bacteriological studies


Certain infections, such as urinary tract infection may have an increased incidence in bladder cancer owing to physiological changes. One mechanism of initiating innate host defenses against bacteria in UTI’s is the production of cytokines. In this study, we investigated prevalence urinary tract infection among bladder cancer patients and the factors associated with the acquisition, and the description of the isolated pathogens in bladder cancer patients. This descriptive study was carried out through the period from January to may 2012 , 40 bladder cancer patients were collected from Baghdad Medical City , Medical City Teaching Laboratories and private laboratories and 20 case controls .The study groups were 40 urine samples from bladder cancer patients ; urine samples taken for tests, and cultures and 40 subjects as health control group from both sexes . The study showed that Staph. aureus was the most common microorganism isolated from UTI which represented (34 %). E.coli was found to be the second most common microorganism encountered in UTI (30.7%) Klebsiela spp. was found to be the third microorganism which represented (11.5%).Proteus spp. was fourth microorganism isolated which represented (15.3%) , while ( 7.6%) of microorganism was Pseudomonas, with p. value > 0.005 that mean no significant differences between the microorganisms that can cause infection in patient with other disease . The study also showed two groups , group (1) was patients with cancer bladder , In this group number of UTI was 65%(male &female) , while 35% of cancer bladder patients were without UTI with non-significant differences . Finally there is non-significant differences among groups of patients with Bladder cancer were divided into five groups , group one included (14) patients (35%) suffering from Bladder cancer only, group 2 included 10 patients (25%) suffering from bl. Cancer and D.M, group 3 included 7 patients (17.5%) suffering from bl. Cancer and hypertension , group 4 included 3 patients (7.5%) suffering from blood cancer and renal failure , group 5 included 6 patients (15.0) suffering from b. cancer and other diseases ( anemia , leukemia, CV and polycythemia).