Estimation of uric acid ,urea, creatinine and creatinine clearance in the serum of preeclamptic women


Preeclampsia is one of the most frequent complication of pregnancy which manifested by high blood pressure during pregnancy for the first time after 20th weeks of gestation with presence of protein in the urine and the causative is unknown. The aim of this study is to estimate serum urea ,serum creatinine, serum uric acid and creatinine clearance in preeclamptic women for feasibility early detection of preeclampsia and prevention of it. Out of 100 pregnant women 50 of them there blood pressure is normal ( uncomplicated pregnancy) and the other 50 were suffered from preeclampsia. The patients chosen when admitted to general Kirkuk hospital from July 2011 to January 2012 .In all 100 pregnant women serum urea, uric acid ,creatinine and urinary creatinine were measured by enzymatic reaction methods, then creatinine clearance rate was calculated by 24 hrs. urine collection . This study revealed that serum urea ,creatinine, uric acid in preeclamptic group were elevated significantly(p< 0.05) in compared to normotensive pregnant group. The creatinine clearance was lower in preeclamptic women than in normotensive pregnant women, the difference was significant (p< 0.05). 45.33% of pre-eclamptic women had positive past medical history of preeclampsia while 64% of them had positive family history of preeclampsia. This study showed that 62% of pre-eclamptic women were primigrivda.Conclusion: It is important to asses renal function tests especially serum uric acid for all pregnant women have high blood pressure as it is the first change and denoter for effecting of renal function in preeclampsia cases.