Role of Adrenaline and nor-adrenaline as a markers in end stage renal failure

Abstract

Renal failure is described as a decrease in glomerular filtration rate. Biochemically, renal failure is typically detected by an elevated serum creatinine level. Epinephrine. Nor epinephrine, a catecholamine with multiple roles including as a hormone and a neurotransmitter. The present study is aimed to early change epinephrine and nor epinephrine levels as markers in end stage renal failure. This study represents a case control study conducted on 60 end stage renal failure patient of both sexes (74%) were male and (26% ) were female in age range from 1 to 30 years (mean 17.9), which carried out during the period from April 2012 to August 2012 in Tikrit Teaching Hospital in renal hemodialysis unit in Tikrit city. Blood samples were obtain from all patients before dialysis put directly into disposable tube with EDTA to get plasma to test epinephrine and nor epinephrine and anther (2ml) put directly into disposable plain tube for blood urea and serum creatine tests. All patients were send for epinephrine and nore-epinephrine after dialysis. The same investigations were done to the control group with nearly same environmental conditions. The total no. of case were 60 patients with similar number of control cases with same age range selected randomly. There was significantly increase in level of epinephrine in all patients. with normal values of epinephrine in all control group. There was statistical differences in Epinephrine level among cases and control group ,The mean + standard deviation of epinephrine level among cases were 49.367 ng /dl + 31.93 , and among control 167.78 ng/dl + 16.53 respectively which is a significant differences. There was a significant relationship in epinephrine level before and after dialysis(epinephrine level decrease significantly after dialysis). Mean +SD for patients before and after dialysis167+31.92 ,132+25.80 respectively. There was a significant relationship between createnine level and epinephrine level before dialysis. There was significantly increasing in level of nor epinephrine in all patients, with normal values of nor epinephrine in all control group (both gender male and female). The mean + standard deviation of nor epinephrine level among cases were 696.08 pg /dl + 33.42 , and among control 313.83 pg/dl + 149.62, which is a significant differences While there was a significant relationship between createnine level and nore-epinephrine level before dialysis. There was a significant relationship in nor epinephrine level before and after dialysis(nor epinephrine level decrease significantly after dialysis). Mean +SD for patients before and after dialysis 690+33.42, 646+38.56 respectively. It is concluded that there was a significant relationship in epinephrine and nor epinephrine level before and after dialysis and there was a significant relationship between epinephrine, nor epinephrine and creatinine before dialysis.