The effect of many plant extracts on the peristalsis of small intestine in the rabbit.


Many plant extracts (P EX) required to treat moderate to severe acute and chronic intestinal pain or diseases. The use of plant extracts give many effects such as inhibitions or activator of gastrointestinal motility (peristalsis). Inhibition of intestinal peristalsis is done by many plants like Ceratonia siliqua (Carob) while activation of intestinal peristalsis is done by others plants such as Senna alexandrina (Senna or Leguminosae) and Salvia officinalis (Labiatae). The main purpose of using Senna is to treat acute constipation, also they use in slimming and laxative herbs. Because of their effects on gut motility is little known; therefore, the effects of low concentration( 0.05,0.1,0.15,0.2,0.25 ) gm/L , and High concentration (0.3,0.35,0.4,0.45,0.5) gm/L of these extracts on intestinal peristalsis in vitro and their mechanisms of action were examined. Peristalsis was recorded in fluid- perfused segments of the rabbit small intestine.The use of aqueous plant extracts and alcohol plant extracts give similar effects to all types of the plants, and all concentrations , with superiority effect of aqueous plant extracts than alcohol plant extracts . Note : (1, 2, 3 ,4 ,5 , 6 ,7, 8 , 9 , 10) ml of stock solution = (0.05 , 0.1, 0.15, 0.2, 0.25 , 0.3 , 0.35, 0.4, 0.45, 0.5 ) gm/L concentration of each plant extract.