Synthesis, Characterization and Study of Biological Activity of Some New Nitrone and Isoxazolidine compounds

Abstract

Two series of new compounds of nitrofuran derivatives I and II were prepared. The first included nitrone compounds synthesized from the reaction of 5-nitrofurfural with N-arylhydroxylamines. The second series, concerned with the synthesis of isoxazolidines by 1,3-dipolar cycloaddition reaction of nitrones with N-phenylmaleimide. The synthesized compounds were characterized by elemental analysis, UV-visible spectroscopy, FT-IR spectroscopy and 1H-NMR spectroscopy. All prepared compounds were screened for their antibacterial activity against two bacterial species, Escherichia coli and Staphylococcus aureus, as well as fungi (Aspergillus niger). The activity data showed that most compounds had good activity as compared with standard drugs. The results of LD50 of some selected compounds showed that some are moderately toxic and others are non toxic in the range of graded doses.