The Effectiveness & Safety of Topical Podophyllin Therapy in Condylomata Acuminata in Iraqi Infants and Young Children


AbstractBackground: Condylomata acuminata an infection caused by Human papilloma virus. The incidence of anogenital warts among children is rising. Still anogenital warts can be the only manifestation of child sexual abuse. Human papilloma virus typing dose not provide definitive evidence for or against sexual abuse.Objective: To evaluate this condition among Iraqi children and to report the experience with podophyllin.Method: Condylomata acuminata was studied in eighteen infants and young children, attending the Department of Dermatology & Venereology- Baghdad Teaching Hospital in Period from January 1996 to January 2000.Results: The ages of patients ranged from 6 – 84 months (mean ± SD23.66 ± 20.30 months), 11 females and 7 males. The duration of the disease ranged from 3 – 8 months (5.83 ± 1.24 months). The clinical pictures were mostly a cauliflower like warts affecting the genital area, anal and perianal areas. Sexual abuse was not confirmed in any case. Family history of genital warts was denied among all family members apart from one girl that her mother had verruca vulgaris on their fingers. Fifteen percent Podophyllin in tincture benzoin was an effective therapy and all lesions had disappeared after 1 – 3 applications (1.77 ± 0.73 months) once weekly with no sign of relapse through several months of follow up.Conclusion: The present work is compatible with the increase in the frequency of genital warts among infants and young children all over the world. Since there was no history of sexual abuse in affected patients, we believe that genital warts result from direct contact with other members of the family, who are either not aware of the presence of warts or they have latent infection. Podophyllin seems to be the drug of choice for all patients who responded quickly to this mode of therapy. This experience with podophyllin in this age group has not been reported in the published literatures.Key Words: Condylomata acuminata, infants & young children, Podophyllin