Thyroid Peroxidase and Thyroglobuline Antibodies as a Marker in Autoimmune Primary Hypothyroidism


Abstract:Background: Autoimmune thyroid diseases are characterized by antibodies (Abs) directed to thyroglobuline (TG) and thyroperoxidase (TPO).Subject & Method: This study was conducted to assess and measure the frequency and the level of the TgAb and TPOAb in sera of 25 patients with autoimmune primary hypothyroidism compared to 15 healthy controls by application of ELISA technique.Results: The results observed that both TgAb (56%) and TPOAb (64%) of all patients were higher than that of the healthy persons TgAb(6.7%) and TPOAb(6.7%), the highest level of both autoantibodies was recorded in 6 women patients with Hashimoto’s thyroiditis (100%) with a level of TgAbs (410 IU/ml) ( P<0.0005) and TPOAbs (525 IU/ml) (P<0.0005).Keywords: Antithyroglobulin Anti-thyroid Peroxidase antibody, Autoimmune Hypothyroidism.