The Effects of Some New Macrolides on Psychomotor Performance in Humans.


Abstract:Objective. The study was designed to show the effects of single oral doses of new macrolides (Clarithromycin, Roxithromycin and Azithromycin) on psychomotor performance by using the computerized Leeds psychomotor Tester...Setting: Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad- Iraq.Design: double-blind, balanced and controlled study.Main outcome measures: Choice reaction time (CRT), recognition reaction time (RRT) movement reaction time (MRT), and critical flicker fusion Frequency (CFF). These parameters were recorded before treatment and 2 hours interval taking 2 readings post treatmentResults: The results showed that the changes in the CRT,RRT ,MRT and CFF values following the three new macrolides treatments ,not significantly different between the four treated groups , nor across the two hours intervals of the study. Conclusion: Single oral doses of the new macrolides Clarithromycin (500 mg) Roxithromycin (150 mg) and Azithromycin (250 mg)have no impairment effects on the sensorimotor and arousal states in . These findings increase the safely profile of the new macrolides.Key wards: Macrolides, Psychomotor Performance, Clarithromycin, Azithromycin, Roxithromycin