Indirect Determination of Chlorpromazine Hydrochloride by Square Wave Voltammetry of Sodium Nitroprusside: Application to Pharmaceutical Formulations

Abstract

An indirect voltammetric method was developed for the determination of chlorpromazine hydrochloride (CPZ) via square wave voltammetric behavior of sodium nitroprusside (SNP) which gives a well-defined square wave voltammetric peak at (-0.589)V against the reference electrode (Ag/AgCl/Sat KCl). The addition of CPZ leads to the decrease of the reduction peak of SNP due to the interaction of SNP with CPZ. The decrease in the peak current (ΔIp) was found to be linear and related to the concentration of CPZ within the range of concentration [(0.490×10-6)-(9.77×10-6)] M with a correlation coefficient of (0.9948). The method had been successfully applied to determine the CPZ in a pure form and in pharmaceutical formulations.