Effect of lead exposure on the development of polycystic ovary syndrome


BackgroundThe effects of Lead and other essential metal like zinc and copper on the reproductive system have been previously reviewed.ObjectiveOur goal in this study was to estimate the levels of Lead, Zinc and Copper in patients with polycystic ovary syndrome and to confirm the effect of such metals on the female reproductive system at environmental exposureMaterials and MethodFifty two women in their reproductive age (20-40) years old, which had been diagnosed as PCQS. Venous blood sample were taken from each patient and control, blood lead, zinc and copper were determined by atomic absorption spectrophotometerHormone assay were determined by ELISA (Enzyme Linked Immune Sorbet Assay) technique.ResultsThis study showed a significant increase of blood lead and serum zinc, copper (p<0.01),jn addition to testosterone, lutenizing hormone, LH/FSH ratio and body mass index (BMI) (p<0.05) in patients with polycystic ovary syndrome when compared with control.ConclusionsOn the basis of the observations of the present study, it can conclude that the increased levels of Lead as a result of the exposure to this metal may be a risk factor for the development of polycystic ovary syndrome in women and has adverse effects on female endocrine and reproductive function,