The Corellation Between the Clinical Diagnosis & Histopathological Findings of Placental Abruption

Abstract

ABSTRACT: BACKGROUND:The diagnosis of placental abruption is mostly clinical, histopathological diagnosis is poorlysensitive. Acute and chronic inflammatory processes had been proposed to cause placentalabruption evidences that supports this remains sparse OBJECTIVE: To assess the correlation between the clinical diagnosis and histopathological findings ofplacental abruption and to examine the profile of chronic and acute histological lesions associatedwith clinical abruption. PATIENTS AND METHOD: The study included fifty singleton pregnant women with a suspected clinical diagnosis of placental abruption compared to fifty consecutive normal pregnancies ( control group), attendingAL -Yarmouk Teaching Hospital over a period of twelve months, from the first of April 2010 tothe end of march 2011 . Examination of the concordance between clinical indicators for placentalabruption with those of a histological diagnosis was done. The profile of acute and chroniclesions was also examined histopathologically. RESULTS: Among the fifty clinically diagnosed placental abruption cases , thirteen percent (fifteen patients)were confirmed as placental abruption based on gross and histological findings . The mostcommon indication leading to a clinical diagnosis of abruption was evidence of retroplacentalclot(s) or bleeding . Acute lesions that were associated with abruption with confirmed pathologyincluded chorioamnionitis , and chorionic villous hemorrhage . Among the chronic lesions,chronic deciduitis, decidul vasculopathy, & dysmaturation were associated with pathologicallyconfirmed placental abruption. CONCLUSION: The relation between clinical & histological diagnosis of placental abruption remains weak. Acute and chronic histological lesions were observed more frequently in placentas of pregnanciescomplicated by placental abruption than the control cases