The study effect of lemongrass oil and effective microorganism (EM) on cholesterol metabolism in rats treated with uranyl acetate

Abstract

Ninety six pubertal albino male rats were used in this study, they were weighed and randomly divided into eight groups. Treatment lasted for 120 days as fallows: G1, control, was given intragastrically (1ml) normal saline, G2, was given intragastrically 75mg/ kg/ b.w Uranyl acetate, G3 was given intragastrically lemongrass oil (3g/Kg), and G4 was given intragastrically Effective Microorganism (EM) (5 g/ Kg), G5 was treated with both Uranyl acetate and then lemongrass oil, G6 was treated with both Uranyl acetate and then (EM), G7 was treated with both lemongrass oil and then Uranyl acetate, G8 was treated with both (EM) and then Uranyl acetate as in G2 and G3 respectively. At the end of the treatment were blood samples were collected, then they were killed to determine the effect of lemongrass oil, (EM) and Uranyl acetate on the following parameters:1.A significant (p<0.05) increase in T.C, T.G, LDL.C and VLDL.C in (G2) and a significant (p<0.05) decrease in HDL-C in comparison with positive control group.2.A Significant (p<0.05) decrease in (T.C, T.G, LDL.C and VLDL.C) was observed in the groups (G5,G6 ) in comparison with (G2) and a significant (p<0.05) increase in HDL-C in (G5,G6) in comparison with positive control group.From these results we can conclude that the treatment with Uranyl acetate has a negative effects, and the active components of lemon grass oil and (EM) reflects an important role in the inhibition of these effects in different parameters that has been taken in consideration in this study.