Study of Glutathione and Total thiol Levels in Irritable Bowel Syndrome Patients


Background: Irritable bowel syndrome (IBS) is a common gastrointestinal condition characterized by abdominal pain and cramps; changes in bowel movements (diarrhea, constipation, or both); gassiness; bloating; nausea; and other symptoms. There is no cure for IBS; however, dietary changes, stress management, and sometimes medications are often able to eliminate or substantially reduce its symptoms.Purpose: It is well do documented that disturbances of oxidant-antioxidant balance in psycho-somatic disease especially in irritable bowel syndrome.Materials and Methods: Glutathione and total thiols were studied in twenty patients aged 18-35 years, compared with twenty sex and age matched healthy subjects.Results: Serum glutathione and total thiol groups levels were significantly decreased in irritable bowel syndrome(IBS) than healthy controls.