Human Leukocyte Antigens and Susceptibility to Atopic Dermatitis


Abstract:Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease belongs to atopic allergic diseases resulting from the interaction between environmental and genetic factors. Many HLA alleles are involved in the etiopathology of atopic dermatitis.Objective: the association between HLA-A, and B genes and the atopic dermatitis.Patients and methods: HLA A and B genotyping were practiced for 40 atopic dermatitis patients and 80 healthy controls using the microlymphotoxicity complement dependent technique.Results: A total of 40 patients with atopic dermatitis were studied. Patients' age ranged from 2 to 48 years with a mean of 19.33± 11.29. The other control group, their ages ranged from 15 to 50 years with a mean of 20.45 ± 12.03. Females were more than males. HLA typing of atopic dermatitis patients showed A9( 14,31.82, 0.17), B6(16, 36.36, 0.20) and B35 (8, 18.18, 0.10) were the highest absolute numbers, phenotype frequencies and genotype frequencies respectively while the control group demonstrated A1(24, 30, 0.16), A2( 28, 35, 0.19), B6(33,, B35(21, 26.25, 0.14) were the dominant ones. There was a significant difference in HLA typing between atopic dermatitis patients and control group in the following alleles (A1, A36, B14, B41, B42, and B53).Conclusions: Genetic factors have a role in the development and expression of atopic dermatitis. Alleles of HLA- A36, B41, B42, B53 had an association with atopic dermatitis Iraqi Arab Muslims patients. Alleles of HLA- A1 and B14 appear to be protective against atopic dermatitis.Key words: Atopic, Human Leukocyte Antigens and microlymphocytotoxicity.