Changes of Liver Enzymes in Coronary Heart Disease

Abstract

background : Coronary heart disease is one of the leading causes of morbidity and mortality elsewhere in the world . An association between liver enzymes and coronary heart disease is suggested.Objective: To evaluate the changes in liver enzymes, Alanine aminotransferases andaspartate aminotransferases in patients with coronary heart disease.Methods: The study included 60 patients with coronary heart disease (41 males and 19 females), and 40 control subjects (25 males and 15 females) from Basrah, Iraq. Alanine aminotransferase, aspartate aminotransferase, lipid profile and fasting blood glucose levels were determined.Results: alanine aminotransferase , aspartate aminotransferase, fasting blood glucose, totalcholesterol, triglycerides, and low density lipoprotein- cholesterol levels were significantlyhigher among coronary heart disease patients compared to controls (P<0.001), while highdensity lipoprotein- cholesterol level was significantly lower among patients with coronaryheart disease in comparison to controls (P<0.001). Alanine aminotransferases revealed asignificant positive correlation with triglycerides (P=0.006), and significant negativecorrelation with high density lipoprotein- cholesterol (P= 0.031) and no significantcorrelations with body mass index, blood pressure, and other biochemical parameters(P>0.05). On the other hand, aspartate aminotransferases showed significant positivecorrelations with total cholesterol (P=0.009), triglycerides (P=0.025) and low densitylipoprotein- cholesterol (P=0.042), and no significant correlations with other physiologicaland biochemical parameters (P>0.05).Conclusions: A strong association exists between changes in liver enzymes, alanine aminotransferase and aspartate aminotransferase and coronary heart disease. These enzymes could be included within the increasing list of coronary heart disease risk factors. Also, they might have prognostic significance and a predictive value in coronary heart disease complications.Key words: Coronary heart disease, liver enzymes, lipid profile.