Comparative study for some antioxidants in correction of oxidative stress markers for experimental induced diabetic rabbits


Determination of reliable biochemical parameters of experimental diabetic rabbit by alloxane monohydrates and role of diatery antioxidants (ascorbic acid, vit. A, and α-tocopherole) supplementation were investigated. Body weight gain, blood (plasma) chemistries, antioxidant enzymes and histopathological lesion were determined over 10 week in new Zealand white rabbits: control T1 group, diabetic T2 group, diabetic and ascorbic acid T3 group, diabetic and Vit. A T4 group, diabetic and α-tocopherole T5 animals group . each of dietary ascorbic acid, vit. A and α-tocopherole that given to animals of T3, T4 and T5 respectively were significantly (P≤0.01) reduced glucose level in blood than T2 diabetic group, also these antioxidants improve levels of cholesterol and triglyceride. Enzymatic activity of liver glutathione peroxidase and superoxide dismutase were significantly increasd more than of diabetic animals T2. histopathological structures of liver and pancrease confirm these results which indicate mild congestion and less degenerative signs in hepatocytes with mild degeneration of langerhans islets, generally oxidative stress resulted from diabetes and may diminished by administration of antioxidant ascorbic acid, Vit. A and α-tocopherole supplementation, and α-tocopherole group was the best group.