Immunological study of patients with asthma

Abstract

An immunological study were performed to estimation the concentrations of immunoglobulin IgE , IL-4 , IL-13 and PGE2 by ELISA , calculate the total and differential WBCs counts of patients with asthma , as well as the relationship between this disease and gender in Babylon province . The study reveals that the IgE and IL – 4 levels were significantly increased (p<0.05) in patients (second and third age categories ) compared with healthy subject . The results illustrated that the patients show a significant elevation in IL – 13 levels in first (p<0.01) , second (p<0.05) and third (p<0.01) age categories respectively compared with control group ;furthermore, the study revealed that the concentration of prostaglandin –E2 (PGE2) show highly significant elevation (p<0.05) in patients compared with healthy individuals . The results displays that there is no significant differences (p<0.05) in total WBCs count between patients and control group , and the same results was in means of neutrophils , lymphocytes and monocytes ; while there were significantly increased (p<0.05) in eosinophils (first and second groups ) and basophils (all groups) in patients compared with healthy subject ,furthermore, the results reveals increased ratio of disease in females compared with males .

Keywords

An immunological study were performed to estimation the concentrations of immunoglobulin IgE, IL-4, IL-13 and PGE2 by ELISA, calculate the total and differential WBCs counts of patients with asthma, as well as the relationship between this disease and gender in Babylon province . The study reveals that the IgE and IL – 4 levels were significantly increased, p<0.05 in patients, second and third age categories compared with healthy subject . The results illustrated that the patients show a significant elevation in IL – 13 levels in first, p<0.01, second, p<0.05 and third, p<0.01 age categories respectively compared with control group, furthermore, the study revealed that the concentration of prostaglandin –E2, PGE2 show highly significant elevation, p<0.05 in patients compared with healthy individuals . The results displays that there is no significant differences, p<0.05 in total WBCs count between patients and control group, and the same results was in means of neutrophils, lymphocytes and monocytes, while there were significantly increased, p<0.05 in eosinophils, first and second groups and basophils, all groups in patients compared with healthy subject, furthermore, the results reveals increased ratio of disease in females compared with males .