Activity assay of plasma fibrinogen in patients with diabetes.

Abstract

Thrombosis secondary to atherosclerosis or hypercoagulability state in diabetes mellitus may be the cause of death in many patients. Patients with diabetes mellitus (n=28, 16 males and 12 females), together with 28 age and sex matched healthy individuals (as controls), were studied after their consent. For each individual (patients and controls), following medical history, 4 ml of venous blood sample was obtained and investigated for HbA1c level, fibrinogen level by doing Claus technique and blood sugar estimation. Hyperfibrinogenaemia in patients with diabetes mellitus (mean plasma fibrinogen 6.8±1.1) is statistically significant (P< 0.05) as compared to control (mean plasma fibrinogen 3.3±1.3). Plasma fibrinogen level is high in patients with diabetes mellitus, suggesting that plasma fibrinogen can contribute to vascular diseases in patients with diabetes mellitus like vascular thrombosis.