Serological Study for TORCH Infections by ELISA Method in Women with Bad Obstetric History in Kerbala City

Abstract

background: Bad obstetric history (BOH) implies previous unfavorable fetal outcomein terms of two or more consecutive spontaneous abortions, early neonatal deaths,stillbirths, intrauterine fetal deaths, intrauterine growth retardations and congenitalanomalies. Maternal infections transmissible in utero at various stages of gestation lead torecurrent pregnancy wastage. Infections caused by TORCH –toxoplasma, rubella virus,cytomegalo virus (CMV) andherpes simplex virus (HSV) – is the major cause of BOH.Objective(S): The study aimed to evaluate the incidence of TORCH infections in womenwith bad obstetric history (BOH).Patients &methods : The study included 130 women with bad obstetric history and 65clinically normal women with previous normal full term deliveries who were attended to thegynecological & obstetrical hospital from January to July 2012. Serological evaluation forTORCH infections was carried out by IgM ELISA method.Result: Seropositivity for toxoplasma was 39.23%, rubella 12.3%, cytomegalovirus 35.38%and herpes simplex virus1.53%. Maximum percent cases of abortion (41.37%) Early neonataldeath (25%) congenital malformation (16.6%) was associated with toxoplasma infection.Maximum percent of cases of abortion (36.20%) Early neonatal death (25 %) congenitalmalformation (33.3%) was associated with cytomegalo infection. while (1.72%) and(13.79%) maximum percent of cases of abortion associated herpes and rubella respectivelyConclusion(S): TORCH infections are associated with recurrent abortion, intrauterine growthretardation, intrauterine death, preterm labor, early neonatal death, and congenitalmalformation. Previous history of pregnancy wastages and positive serological reactionsduring the current pregnancy must be considered while managing BOH cases so as to reducethe adverse fetal outcome.