Serum Anti-Müllerian Hormone (AMH) in Prediction of Oocyte Quality and in Vitro Fertilization (IVF) Outcome


ABSTRACT:BACKGROUND: Growing evidence indicates that serum Anti-mullerian hormone (AMH) levels could be of great importance for understanding the relationship with oocyte quality for IVF. The aim of the present study was to investigate the role of serum level of AMH in differentiation of infertile female patients with good quality oocytes, who are good responder and ready to enter the IVF cycles.OBJECTIVE:This study included 25 infertile females classified into two groups: (15) females with Tubal obstruction and 10 females with polycystic ovary syndrome (PCOS). Also, nineteen fertile females were served as controls.METHODS:Investigation included serum measurements of AMH, Inhibin B, FSH, LH, E2, Prolactin and TSH on day 3 of previous menstrual cycle, serum measurement of progesterone (P4) on day 21 of previous menstrual cycle (before starting ovulation induction). Also AMH, Inhibin B and E2 were measured on day of hCG administration (after long ovulation protocol). RESULTS: The mean (±SD) value of serum AMH was significantly decreased in female patients after ovarian stimulation protocol compared to that before ovarian stimulation,(P< 0.01). Also, the mean (±SD) value of serum AMH of female patients with good quality oocyte was significantly higher than that of those with bad quality oocyte, (P<0.01). CONCLUSION: This study revealed that measurement of serum AMH is good marker in prediction of good responder infertile females for IVF technique after ovarian stimulation protocol.