Glycosylation gap in a group obese subjects


Back ground: Obesity is major health problem worldwide that increase risk for a wide range of diseases including diabetes mellitus and heart disease. As such, it increasingly important to understand how excess adiposity can perturb normal metabolic functions specially for glucose and lipid homeostasis.Objectives: The study design to evaluate the effects of obesity on the glycosylation process and determine the effects of increase age and BMI on measured parameters. Materials and Methods: This study was conducted during the period from October 2010 to September 2011 in the department of Clinical Pharmacy under approval of scientific and ethics committee. One hundred individuals were included in this work divided into 2 groups. The first group included fifty apparently healthy individuals (30 males and 20 females) with BMI (21±3.1 Kg/m2). The second group included fifty individuals (30 males and 20 females) with BMI (28.± 1.3 Kg/m2) whose defined as obese.Results: The study demonstrated a significant elevation in serum glucose, mean blood glucose, serum fructosamin, measured and predicted HbA1c in obese individuals as compared with those of control individuals. Glycosylation gap showed a significant elevation in obese subjects when compared to control individual that mean significant elevation in intracellular glycosylation process. Regarding the relation between age and measured parameters, the study showed no significant correlation between age and measured parameters in the control group, while in obese group there were a significant correlation( r = 0.03) between ages and predicted HbA1c and BMI( p ≤ 0.05).Regarding the relation between BMI and measured parameters, the study showed significant correlation between measured parameters and BMI in obese individuals, while in control group only serum glucose and MBG were correlated to BMI ( r = 0.01) at ( p ≤ 0.05).Conclusion: obese subjects shows significant increase in glycosylation gap, so there is a significant intracellular glycosylation process that was related to many diseases process and their complication.