Serum Lipids in Diabetic and Hypertensive Patients Attending Clinic in Aba Metropolis, South-Eastern Nigeria


Systolic and diastolic blood pressures and body mass index were carried out in 150 patients attending Abia State Teaching Hospital, Aba, South-Eastern part of Nigeria, and in another 50 persons from the same locality, who were neither hypertensive nor diabetic (controls); bringing to total number of participants to 200. The result showed that the mean total cholesterol (TC) 6.73±1.19 mm/L, triglyceride (TG) 2.66±0.83 mm/L, low density lipoprotein cholesterol (LDL-C)3.84±1.07mm/L, and fasting blood glucose (FBS)10.19±3.69mm/L were significantly higher (P<0.05) in hypertensive diabetic subjects compared with the control subjects with values: TC 4.59±0.94mm/L, TG 1.59±0.33mm/L, LDL-C 2.8±0.49mm/L. The systolic and diastolic blood pressures were also significantly higher (P<0.05) in hypertensive diabetics 172.00±12.21 mmHg, and 105.50±9.96mm/Hg, respectively, compared with the control subjects 120.56±13.79mmHg, and 76.8±8.5mmHg respectively. The mean serum levels of high density lipoprotein cholesterol (HDL-C) in hypertensive and diabetic patients: 0.89±0.58mm/L was significantly lower at (P<0.05) than of control: 1.71±0.40mmHg. The mean levels of TC, TG and LDL-C, were significantly higher (P<0.05) in hypertensive non diabetic subjects compared with normal healthy subjects studied. The HDL-C of non diabetic hypertensive subjects: 0.96±0.45mm/L was significantly lower at (P< 0.05) than values obtained in control subjects:. 1.71±0.40mm/L. The mean glucose level showed no significant difference (P>0.05) between the hypertensive non diabetic subjects and control subjects. No significant difference was found in the mean body mass index (BMI) of the hypertensive, diabetic and control subjects. The findings, which provide data from the South –Eastern part of Nigeria, agree with literature report on effect of diabetes and hypertension on the blood level of these parameters in persons from other localities. Of particular interest is the level of HDL-C and TC in both hypertensive and diabetic patients which is suggestive of the higher risk of developing cardiovascular disease. The results underscore the necessity of carrying out complete lipid assay and FBS in patients who present either of these conditions. This should be in addition to looking out for other clinical manifestations of the diseases and following up treatment.