Oxidative Stress Induced Histological Changes in Thyroid of Hypothyroidism Patients

Abstract

Abstract:Hypothyroidism is a condition resulting from insufficient production or diminished actionof either T3 and/or T4 thyroid hormones.The present study is to look for a correlation between oxidative stress and histological changes ofthyroid gland in hypothyroidism patients.30 hypothyroidism patients and 30 healthy individualsas control subjects were included in the study.We measured their serum tri-iodothyronine, thyroxin and thyroid-stimulating hormone(T3, T4, TSH) respectively. Estimation of MalondyIdehyd (MDA) and Glutathione (GSH) inserum and in homogenized thyroid tissue was carried out by standard methods. TSH waselevated in both serum and in homogenized tissue of patients compared to controls, while T4 andT3 were significantly lower in the patients than in controls. Melanodyldehyd (MDA) as LipidPeroxidation marker were significantly higher in both serum and in homogenized tissue ofpatients than in the controls, while(GSH) were significantly lower in both serum and inhomogenized tissue of patients than in the control subjects.Hypothyroidism patients showed histological changes in thyroid gland tissues include,hyaline thickness of the blood vessel walls, necrotic follicles, a strong inflammatory reaction,and peeling of necrotic cells in the follicles.