THE CYTOTOXICITY AND GENOTOXICITY EFFECT OF DRUG SUSTANON "100" ON MALE GERM CELLS OF MUS MUSCULUS

Abstract

In this study the effects of three doses (0.01, 0.02, 0.04 mg/kg) of Sustanon "100" has been investigated in male germ cells of Musmusclus. Five tests has been done the first is mitotic index, micronuclei, chromosomal central associated, chromosomal aberration and head sperm abnormalities. These doses induced significantly higher number of mitotic index,micronuclei, chromosomal central associated, chromosomal aberration (chromosomal, chromatid break, fragments, ringchromosome) especially after 21–35 day and also it has been found the sustanon has the ability to induce sperm head. Abnormalities at equal rate in control. For these side effects which have seen early during the course of treatment, so the treatment should be discontinued or appropriate therapy instituted after consult a medical.