Effect of hydrochlorothiazide with amiloride on serum lipidprofile and malondialdehyde in hypertensive women


Objectives: To study the effect of hydrochlorothiazde with amiloride on serum lipid profile and malondialdehyde (MDA) in hypertensive women.
Methods: A case-control study was carried out in the Outpatient Department in Ibn-Sina General Hospital, Mosul, during the period from November 2005 to May 2006. Thirty hypertensive women treated with 50 mg hydrochlorothiazide and 5 mg amiloride per day in a single dose. The duration of treatment was between 1-5 years. Thirty mild hypertensive women (newly diagnosed, before treatment) were also included as a control group. Blood samples were taken from both the treated patients and controls and analysed for serum lipid profile and MDA. Non-paired 't-test was used to compare between parameters.
Results: Hydrochlorothiazide with amiloride did not change serum lipid profile significantly in the hypertensive women compared with the control group, although serum lipid profile was in the upper normal value. The combination therapy decreased serum MDA significantly (P<0.05).
Conclusion: Chronic use of combination therapy of hydrochlorothiazide with amiloride had no significant effect on serum lipid profile, but this combination reduced lipid peroxidation in hypertensive women. Lipid peroxidation is a consequence and not a cause of hypertension.
Keywords: Lipid profile, lipid peroxidation, malondialdehyde, hypertensive women.