Thyroid Disorders and the Level of Malondialdehyde


Background: Free radicals have been implicated in many pathological processes, includingischemia, inflammation, and malignancy. The free radicals may affect tissues damage by lipidperoxidation which generate malondialdehyde (MDA) as a by byproduct of the reaction. Theobjective of this study is to examine the dynamics of lipid peroxidation in patients withthyroid disorders using the measurement of malondialdehyde level as a marker for the degree ofthyroid disorder.Methods: Two hundred and forty five subjects were enrolled in this study. Hundred andninety five were patients with different thyroid disorders (88 yperthyroidism, 63hypothyroidism and 44 thyroid carcinoma) the remaining 50 subjects were healthy oneswithout any apparent functional disorders served as a control. Malondialdehyde (MDA) levelwas estimated in the sera of all subjects.Results: A significant increase in the level of serum MDA concentration was observed inpatients with all types of thyroid disorders as compared with the control groups.Conclusion: The findings obtained showed a high