Serum Interleukin-8 and Hs-C Reactive Protein Determination in Iraqi Multiple Sclerosis Patients: Case Control Study


ABSTRACT: BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease caused by a complex disorder that cluster many common diseases in children and adults, leading to chronic inflammatory disease of the central nervous system with morphological hallmarks of inflammation, demylination, axonal loss and gliosis .Factors responsible for MS and its progression are still not fully understood, but it has been suggested that both environmental determinants and genetic susceptibility are involved.OBJECTIVE :The aim of this study is to evaluate the role of inflammatory markers ;hs-CRP and IL-8 in pathogenesis of MS and to see the correlation between them.PATIENTS AND METHODS: Twenty one MS Patients (7male,14 female) attending the MS Clinic at Baghdad teaching hospital, their ages range between( 20-32) years (15) age- and sex- matched healthy control participated in the study. Investigations included serum measurements of high sensitive C-reactive protein (hs- CRP) and interleukin-8 in patients and control groups.RESULTS: The result of the present study showed significant increase in both CRP(p<0.001 ) and IL-8 (p< 0.001 ) in the serum of MS patients compared to control.CONCLUSION: There is evidence that neuroinflammatory process due to elevation of CRP and IL-8 has an important role in MS .