Association between preeclampsia and hyperandrogenemia

Abstract

Background; Insulin resistance and increased serum free testosteroneare well known to be associated with preeclampsiaType of study; case controlAim of the study; to compare serum levels of free testosterone amonghypertensive preeclamptic women versus controlMethods; two groups were constructed from primigravida womentaken from labor ward. Study group (N=30) were preeclamptic versuscontrol (n=30). For all women serum testosterone was assayed andcompared and correlated to mean arterial blood pressure and othervariables in preeclampsiaResult; serum free testosterone was significantly higher among womenwith preeclampsia compared with control 5.00±0.72 versus 1.28±0.97, P< 0.001. No Significant change was found between serum estriol levelsin both groups. Analysis of co-variants has shown that fetal gender(Male) has no effect on maternal serum testosterone levels.Conclusions; preeclamptic women in the third trimester havesignificantly higher free testosterone serum levels than control women.It is not clear yet whether this increase in free testosterone is related toinsulin resistance in the placenta or other factors. Further studies arerequired to explore the significance of increased testosterone levels inthe blood with prediction of preeclampsia and assessment of itsseverity.