This study was conducted to investigate the effect of using seasame seed meal on some physiological traits of sharabi calves, on Al-Rasheida station farms, Mosul, from 17/10/2012 to 17/2/2013.Twelvth sharabi local calves were used at age 8-10 months and 135-160 kg.live body weight and divided into three groups according to their live body weight. All groups of calves were fed iso-nitrogen (15.5% CP) and iso-caloric (27.99 Mcal/kg.ME.) rations but different in percentage of seasame seed meal (0, 18 and 23%) for four months. Blood samples were withdrawal from jugular vein from each animal during experiment period to investigate the effect of seasame seed meal percentage on some physiological parameters of blood. The results revealed that using seasame seed meal have un significant effects on all hematological parameters, while red and white cell count ,hemoglobin packed cell volume, Lymph-ocyte percentage were increased significantly (p≤0.05). Acidophil and netrophil cells percentages were decreased significantly (p≤0.05) by animals get older. Concentration of total protein and globulin were increased significantly (p≤0.05), while the concentration of triglycerides and cholesterol were decreased significantly (p≤0.05) by increasing the percentage of sesame seed meal in ration and animal get older. Concentrations of AST, ALT, calcium, phosphorus, sodium, chlorine, potassium and magnesium were not effect it by Sesame seed meal and animal age. It was concluded that adding of sesame seed meal instead of soybean meal in the rations for local Sharabi calves without any negative effect on the physiological parameters studied.