TY - JOUR ID - TI - Assessment of serum and salivary malondialdehyde in patients with oral lichen planus AU - Aws Waleed Abbas اوس وليد عباس AU - Taghreed Fadhil Zaidan تغريد فاضل زيدان AU - Abduladheem Y. Abbood Al-Barrak عبد العظيم عبود البراك PY - 2014 VL - 26 IS - 2 SP - 99 EP - 102 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - Background: Free radicals are common consequences of normal aerobic cellular metabolism. Oxidative stressresulting from the increased production of free radicals and reactive oxygen species and/or a decrease inantioxidant defense leads to damage of biological macromolecules and dysregulation of normal metabolism andphysiology. Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease of unknown cause. It has beenproven that the imbalances in free radical levels and reactive oxygen species with antioxidants may play a key rolein the onset and evolution of several inflammatory oral pathologies. The aim of this study was to assess the role ofoxidative stress in the pathogenesis of OLP through the study of serum and saliva malondialdehyde as a marker ofoxidative stress.Methods: The study included (48) patients with OLP (21) with the reticular form and (27) with erosive form and (32)healthy looking volunteers that were age-matched with the patients. Serum and saliva malondialdehyde wasmeasured by reacting with thiobarbituric acid under acidic conditions and heating to a pink color that measuredspectrophotometricaly at 532 nm.Results: the mean of serum and saliva malondialdehyde in oral lichen planus patients group was significantly higherthan that of control group (p<0.01 and p<0.05 respectively) and there was no statistically significant differences inserum and saliva malondialdehyde when compared between reticular and erosive forms (p>0.05). The study showedthat there was no statistically significant correlation between serum and saliva malondialdehyde levels in OLPpatients group (r= 0.053, p>0.05).Conclusion: Increased serum and salivary malondialdehyde levels refer to the role of oxidative stress in thepathogenesis of OLP.

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