@Article{, title={Salivary High Sensitive C-Reactive Protein and Gingival Health Status among a Group of Women with Polycystic Ovary Syndrome}, author={Dr. Andalus Abid Hassan Tahir B.D.S. د. اندلس عبد حسن and Dr. Baydaa Hussien B.D.S, M.Sc. د. بيداء حسين}, journal={MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان}, volume={13}, number={1}, pages={38-45}, year={2016}, abstract={Background: Polycystic ovary syndrome (PCOS) is the most common endocrinedisorder affecting women in their reproductive years. It is a complex disorderaffects not only general health but also show a reciprocal link with the oral health.C-reactive protein is an acute phase protein which increase their concentrationduring certain inflammatory disorders and used as a biomarker of inflammation inthe body. The aims of this study were to assess the gingival health status among agroup of women with polycystic ovary syndrome as well as to estimate the levelsof salivary high sensitive c-reactive protein in unstimulated saliva in relation togingival health condition.Materials and methods: Sixty two females with an age range 20-25 years old andwith a body mass index range18.5-24.9 (normal weight) were included in thisstudy. They were divided into two groups; the study group which included thirtyone females with polycystic ovary syndrome, those females attended BabylonTeaching Hospital/ Infertility Center with regular cycles, without clinical orbiochemical features of hyperandrogenism and ultrasound exclusion of polycysticovary (without polycystic ovary syndrome). Collection of unstimulated salivarysamples was carried out under standardrized conditions, salivary high sensitive creactiveprotein levels were estimated. Plaque index of Silness and Lӧe (1964)was used to assess dental plaque. While gingival index of Lӧe and Silness (1963)was used to assess gingival inflammation.Results: Results showed that the mean value of plaque index was found to be higherin the control group (1.18±0.03) than that in the study group (1.00±0.08) withstatistically highly significant difference (p<0.01).While the mean value ofgingival index was higher among the study group (1.52±0.06) than that in thecontrol group (1.31±0.05) with statistically highly significant difference (p<0.01).salivary levels of high sensitive c-reactive protein among women with polycysticovary syndrome (1061.68±75.41 pg/ml) were found to be higher than that ofcontrol (930.51±94.65) with statistically highly significant difference(p<0.01).The results in this study showed that the correlations between salivaryhigh sensitive c-reactive protein with gingival index were statistically highlysignificant (p<0.01)in women with polycystic ovary syndrome.While statisticallyno significant correlation between plaque index and high sensitive C-reactiveprotein(p˃0.05).In order to assess the specificity and sensitivity of the use of salivary highsensitive c-reactive protein as a diagnostic tool, statistical analysis of ReceiverMDJOperative Characteristics Curve (ROC) was used and predictive ValueMeasurments were done in this study. The results showed that the area under thecurve for salivary high sensitive c-reactive protein test was (0.869) with highlysignificant p-value (p<0.01). The best optimal cut off point for salivary highsensitive c-reactive protein was (1009) with (71%) sensitivity and(96.8%)specificity, indicating a very good predictive capacity for using salivaryhigh sensitive c-reactive protein as a marker for the diagnosis of polycystic ovarysyndrome.Conclusions: It was concluded that gingival inflammation was high among womenwith polycystic ovary syndrome. Furthermore, salivary levels of high sensitive creactiveprotein were found to be high among women with polycystic ovarysyndrome. It was suggested that the measurement of salivary high sencitive creactiveprotein may be helpful in diagnosis of women with polycystic ovarysyndrome.

} }