TY - JOUR ID - TI - PATHOPHYSIOLOGICAL EVALUATION OF THE PROTECTIVE ROLE OF ALPHA LIPOIC ACID ON DIABETES MELLITUS NEPHROPATHY IN MALE RABBITS AU - Jihad Abdulameer Ahmed PY - 2017 VL - 16 IS - 1 SP - 100 EP - 119 JO - Basrah Journal of Veterinary Research مجلة البصرة للابحاث البيطرية SN - 18138497 24108456 AB - In order to estimate the ameliorating effects of alpha lipoic acid (ALA) on thenephropathy of diabetes mellitus (DM) associated with oxidative stress, this studyperformed in 18 adults male rabbits were divided into 3 equal groups, the group-I wasregard as control while group-II Induced DM only by intravenously single dose (150mg/kg b.w.) of alloxan-monohydrate; group-III was induced DM by intravenouslysingle dose of (150mg/kg b.w.) of alloxan-monohydrate and then treated by (10mg/kgb.w.) daily of ALA intraperitoneally for 4 weeks. The biochemical results showedsignificant (P≤0.05) decreased of the serum values of GSH, CAT and SOD as well,significantly (P≤0.05) increased of MDA, peroxynitrate, creatinine and BUN ofgroup-II when compared to control; also the result of group-III showed nonsignificant(P˃0.05) differences of GSH, SOD, MDA, creatinine, BUN andperoxynitrate when compared to control. The histopathological and histochemicalresults of kidney of group-II showed moderate thickness of basement membrane ofglomeruli with compressed capillaries as well infiltration of glyco-proteinaceousmaterials in glomeruli and around renal tubules with some vacuolation of thesetubules and mesangial cells; while the results of group-III showed normalarchitectures with very mild degree of vacuolation of few renal tubules in addition todisappearance of glyco- proteinaceous materials in this group; in conclusion, ALAhad a dual protective effects on nephropathy by scavenging the oxidative stress freeradicals and enhanced insulin metabolism.

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