TY - JOUR ID - TI - Serum and salivary levels of proinflammatory cytokines as potential biomarkers in the diagnosis of oral squamous cell carcinoma AU - Abdul-Wahab R. Hamad AU - Shanaz M. Gaphor AU - Nazar G. Al Talabani PY - 2009 VL - 21 IS - 1 SP - 60 EP - 65 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - ABSTRACT
Background: Oral squamous cell carcinoma is one of the prevalent cancers of the body . If not treated at its early
stages, the prognosis will be poor. Early diagnosis of oral cancer may not be easy clinically because of its
resemblance to a number of benign lesions in the mouth. The aim of the study was to evaluate the validity of
measurement of some proinflammatory cytokines levels in serum and saliva as biomarkers for early detection of oral
cancer.
Materials and methods: The levels of Interleukins IL-1α, IIL-6, IL-8 and Granulocyte Macrophage-Colony Stimulating
Factor (GM-CSF) in the serum and saliva of (30) patients with OSCC and (20) healthy (control) individuals were
measured by enzyme linked immunosorbent assay (ELISA).
Results: Higher concentrations of serum IL-6 and IL-8 levels were observed in patients with OSCC than the control
group (P<0.001). No significant difference was seen in serum IL-1 alpha and GM-CSF between patients with OSCC
and control group. The levels of IL-1 alpha, IL-6, IL-8 and GM-CSF in saliva showed significant increase in patients
with OSCC when compared with control group.
Conclusion: It is concluded that the levels of certain prinflammatory cytokines can be measured in serum and saliva
of patients with OSCC and healthy individuals. Detection of increased levels of these elements can be used as
biomarkers for early detection of oral cancer,
Keywords: oral cancer; saliva, serum, cytokine, interleukine. (J Bagh Coll Dentistry 2009; 21(1): 60-65)

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