TY - JOUR ID - TI - Detection of SCN1A Gene Polymorphisms in Epilepsy Children AU - Laith Abdul Hassan Mohamed-Jawad1 PY - 2017 VL - 4 IS - 2 SP - 34 EP - 40 JO - Muthanna Journal of Pure Science (MJPS) مجلة المثنى للعلوم الصرفة SN - 22263284 25725181 AB - Febrile seizure is a common convulsions occur in children from 5 months to 6 years of age whose sufferingfrom high temperature. A total of 50 children with febrile seizures and 50 normal control are included in this study.RFLP used to identify the A/G polymorphisms of the SCN1A gene on chromosome 2q24. Results showed that thegenotype proportions and allele frequencies for SCN1A c.3184 A/G in both groups are not significantly. Proportions ofA homozygote, A/G heterozygote, and G homozygote for SCN1A c.3184 A/G were as follows: in patients with FSs,20%, 50%, and 30%, respectively compared to controls (24%, 62%, and 14%, respectively). The allele A and Gfrequencies for SCN1A c.3184 A/G in patients with FSs was 45% and 55% respectively compared to control group. Thefrequency of AG genotype of SCN1A c.3184 A/G polymorphism was non-significant in FSs compared to control group.There was increased in glucose, phosphorus levels and decrease in sodium, chloride levels. The results do not suggestthat SCN1A p. Thr 1067 Ala or c.3184A/G (rs2298771) are susceptibility factors for febrile seizures and the fever playsan important role in causing disturbances in electrolyte balance.

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