TY - JOUR ID - TI - EFFECT OF URSOLIC ACID, HYPERINSULINEMIA AND VITAMIN B COMPLEX ON SOME BIOCHEMICAL PARAMETERS AND SKELETAL MUSCLE HISTOLOGY OF ALLOXAN INDUCED DIABETIC RABBITS AU - Shaymae' H. Shabaa AU - Abdul Razzaq N. Khudair PY - 2017 VL - 16 IS - 2 SP - 259 EP - 270 JO - Basrah Journal of Veterinary Research مجلة البصرة للابحاث البيطرية SN - 18138497 24108456 AB - This study aimed to evaluate the effect of ursolic acid, hyperinsulinemia and vitaminB complex in skeletal muscle, which represented by Gastrocnemius muscle after sciaticnerve crush in diabetes mellitus male rabbits, determine their effects on somebiochemical parameters which include insulin, total serum protein (TSP) and skeletalmuscle protein percentage and detect their effects on histological structures of the skeletalmuscle represented by Gastrocnemius muscle. The results of our study showed that thereis a significant increase of insulin in diabetic rabbits and this increase is continued in alltreatment groups with a higher level range of (3.56-8.4 µu/ ml); the lowest significantincrease is with vitamin B complex treated group. Our study illustrated that Induction ofdiabetes has no significant effect on skeletal muscle protein percentage but has asignificant effect on total serum protein, while all treatment groups caused a significantincrease in skeletal muscle protein percentage and total serum protein. Histologicalsections of the Gastrocnemius muscle represent some changes happened due to sciaticnerve crush injury, such as some distraction in skeletal muscle fibers, splitting andatrophy of others as well as there is an increase in thickness of fibrous tissue separatingthem. There is a good regeneration of muscle fibers with little splitting phenomena; alsothere is a clear formation of muscle cell nuclei, which indicate an improvement of muscleafter different treatment.

ER -