TY - JOUR ID - TI - 12-TOXICOPATHOLOGICAL AND BIOCHEMICAL STUDY OF MULTIPLE DOSES DIGOXIN IN SPRAGUE DAWLEY RATS AU - Abbas A. Khadhair* , Saleh K. Majeed PY - 2018 VL - 17 IS - 1 SP - 136 EP - 146 JO - Basrah Journal of Veterinary Research مجلة البصرة للابحاث البيطرية SN - 18138497 24108456 AB - The current study was conducted at the college of veterinary medicine, university ofbasrah in the periods extended from 22/10/2016 to 22/1/2017. The present study isdesigned to report the toxic effects of digoxin on kidney histologically and biochemicallyby measuring kidney parameters urea and creatinine level in the serum. Maximum toxicdose determined by using 2 rats dosed orally until clinical signs of toxicity becameprominent at 30mg for each rat and considered as MTD. The chronic toxicity study wascarried out on 48 adult rats divided into 4 groups. Control (G1) receive distilled water,Low dose (G2) dosed with 1/20 MTD(1.5mg/kg) digoxin, Intermediate dose (G3) dosedwith 1/10 MTD(3mg/kg) digoxin and High dose (G4) dosed with 1/5 MTD(6mg/kg)digoxin by oral gavage for 90 days. At the end of experiments all animals were sacrificedand blood sample were collected for estimation of biochemical parameters of rat. Resultreveals histopathological changes presented as dilation/vaccuolation of renal tubules andatrophy of glomeruli. There is a significant (P≤0.05) increase in serum urea andcreatinine level in high dose (G4) group when compared with other study group. Weconclude that high dose digoxin has toxic effect on renal tissue and lead to their damage.

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