@Article{, title={Salivary and Serum Levels of Both Uric Acid and C-Reactive Protein (CRP) Biomarkers in Patients with Behçet's Disease}, author={Noor H. Mohammad}, journal={Tikrit Journal for Dental Sciences مجلة تكريت لعلوم طب الاسنان}, volume={5}, number={1}, pages={143-149}, year={2017}, abstract={Behçet's disease (BD) is a systemic vasculitis identified by recurrent oral and genitalulcerations, skin inflammations and uveitis, with unknown etiology. This study had beendesigned to assess the level of salivary and serum uric acid (UA) and C - reactive protein(CRP) markers in BD patients as activity markers and to explore their relations in diseaseexistence. Fifty BD patients :( 32 males and 18 females) with mean age (35.3 ± 7.6) yearsand fifty healthy subjects (30 males and 20 females) with mean age (34.8± 9.1) years wereinvolved in this study that extend during the period of (2014-2016). All of patients andhealthy subjects were analyzed for UA by (colorimetric spectrophotometric assay that basedon oxidation of UA by uricase enzyme to allantoin) and CRP by (qualitative analysis:antigen-antibody interaction Latex agglutination test) in both saliva and serum. Data wasanalyzed using descriptive statistics, t-test, P (ANOVA) test, Chi-square (2) test, andPearson’s linear correlation coefficient statistical analyses. Results of this study show thatsalivary uric acid was significantly elevated in BD patients than in healthy subjects.(P<0.001). Although serum UA was higher in patients than the healthy subjects butstatistically not significant. (P=0.57). On the other hand, out of fifty patients there werethirteen patients (26%) significantly expressed CRP positive in their serum and saliva. Theresults of this study revealed that UA can act as prooxidant (pro inflammatory) marker andCRP as inflammatory marker that could be related to impaired endothelial

} }