TY - JOUR ID - TI - Assessment the impact of zinc and copper on GST, ALP in blood of cancer patients AU - Iqbal Fadhil Alwan , Ammar Mawla Hamood PY - 2017 VL - 16 IS - 3 SP - 149 EP - 158 JO - Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية SN - 18154794 25207245 AB - Breast cancer is a highly heterogeneous disease globally. The absolute risk of breast cancer increases with age for women . Study the role of trace elements in the blood such as (copper and zinc) and biomarkers breast cancer diagnosis such as GST, ALP . had been measured in serum of 60 women with breast disease , divided to :. the first group (A) (30) women benign breast tumors , the second group (B) (30)women breast cancer. Evaluated of serum copper and zinc of breast cancer women was determined by atomic absorption spectrophotometry , and the level of (GST)(Glatathione – S- transfers) enzyme and ALP(Alkaline phosphates ) enzyme compared with control group. The results showed a significant increase ( p<0.001) in the level of enzyme (Glatathione – S- transfers) and the (Alkaline phosphates)enzyme in serum breast cancer group , while we observed a slight increase ( p<0.01) in benign tumor group compared to the control group. However , there was a significant decrease in the level of the zinc element compared with the control group and a rise in the level of the copper element, which means copper /zinc ratio in patients was higher than in ontrolgroup.

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